Demirbag Recep, Sezen Yusuf, Yeşilay Asuman Biçer, Bas Memduh, Yildiz Ali, Guntekin Unal, Aksoy Nurten
Department of Cardiology, Medical Faculty of Harran University, Sanliurfa, Turkey.
Coron Artery Dis. 2011 Aug;22(5):289-93. doi: 10.1097/MCA.0b013e3283458a7d.
The serum paraoxonase and arylesterase activities are related to coronary artery diseases. However, there are a few data about the association of paraoxonase and arylesterase activities with in-stent restenosis (ISR). The aim of this study was to evaluate the relationship between paraoxonase and arylesterase activities and ISR in patients with bare metal stent (BMS).
Thirty-one patients with normal coronary artery (group 1) and 60 with BMS were enrolled in this observational study. According to the ISR, the patients were classified as group 2, without the ISR (n=29) and group 3, with the ISR (n=31). Serum paraoxonase and arylesterase activities were measured spectrophotometrically.
The paraoxonase and arylesterase activities were lower in patients with BMS than in the individuals with normal coronary artery (P < 0.001 and P = 0.001, respectively). The enzyme activities were also higher in patients without ISR than with ISR (both of P < 0.001). In bivariate correlation analyses in patients with BMS, ISR shows significant positive correlations with the presence of hypertension and hyperlipidemia, type C lesion, and stent length, but shows negative correlations with type A lesion stent diameter, high-density lipoprotein cholesterol, and paraoxonase and arylesterase activities. In regression analysis, ISR is independently associated with paraoxonase and arylesterase activities (β = -0.216, P = 0.038 and β = -0.452, P < 0.001, respectively), type A lesion (β = -0.251, P = 0.013), and stent diameter (β = -0.192, P = 0.024) in patients with BMS.
Our study shows that decreased paraoxonase and arylesterase activities play a significant role in ethiopathogenesis ISR in patients with BMS.
血清对氧磷酶和芳基酯酶活性与冠状动脉疾病相关。然而，关于对氧磷酶和芳基酯酶活性与支架内再狭窄（ISR）之间关联的数据较少。本研究旨在评估裸金属支架（BMS）患者中对氧磷酶和芳基酯酶活性与ISR之间的关系。
本观察性研究纳入了31例冠状动脉正常的患者（第1组）和60例植入BMS的患者。根据ISR情况，患者被分为第2组，无ISR（n = 29）和第3组，有ISR（n = 31）。采用分光光度法测定血清对氧磷酶和芳基酯酶活性。
BMS患者的对氧磷酶和芳基酯酶活性低于冠状动脉正常的个体（分别为P < 0.001和P = 0.001）。无ISR患者的酶活性也高于有ISR患者（均为P < 0.001）。在BMS患者的双变量相关性分析中，ISR与高血压、高脂血症、C型病变和支架长度呈显著正相关，但与A型病变、支架直径、高密度脂蛋白胆固醇以及对氧磷酶和芳基酯酶活性呈负相关。在回归分析中，ISR与BMS患者的对氧磷酶和芳基酯酶活性（分别为β = -0.216，P = 0.038和β = -0.452，P < 0.001）、A型病变（β = -0.251，P = 0.013）和支架直径（β = -0.192，P = 0.024）独立相关。
我们的研究表明，对氧磷酶和芳基酯酶活性降低在BMS患者ISR的发病机制中起重要作用。
