Camuzcuoglu Hakan, Arioz Dagistan Tolga, Toy Harun, Kurt Sefa, Celik Hakim, Erel Ozcan
Harran University, Faculty of Medicine, Department of Obstetrics and Gynecology, Sanliurfa, 63100, Turkey.
Gynecol Oncol. 2009 Mar;112(3):481-5. doi: 10.1016/j.ygyno.2008.10.031. Epub 2008 Dec 20.
The HDL-associated paraoxonase and arylesterase activities play a role in decreasing oxidative stress, which is known to contribute to cancer development. The aim of this study was to evaluate serum paraoxonase and arylesterase activities and lipid hydroperoxide (LOOH) levels in patients with newly-diagnosed epithelial ovarian cancer.
Serum paraoxonase and arylesterase activities, total free sulfhydryl (-SH) levels and LOOH levels were measured in patients with epithelial ovarian cancer (n=24) and controls (n=29).
Serum paraoxonase activity and arylesterase activity, as well as -SH levels were significantly lower (p=0.003, p<0.001 and p<0.001, respectively) in patients with epithelial ovarian cancer compared to controls, while LOOH levels were significantly higher (p<0.001). A significant inverse correlation was found between the stage, grade and CA-125 level of ovarian cancer and paraoxonase activity (rho=-0.630, p=0.001 and rho=-0.601, p=0.002 and rho=-0.436, p=0.033, respectively), arylesterase activity (rho=-0.601, p=0.002 and rho=-0.713, p<0.001 and rho=-0.580, p=0.003, respectively), and -SH levels (rho=-0.642, p=0.001 and rho=-0.637, p=0.001 and rho=-0.530, p=0.008, respectively). In contrast, there was a positive correlation between LOOH and the stage, grade and CA-125 level of ovarian cancer (rho=0.565, p=0.004 and rho=0.479, p=0.018 and rho=0.642, p=0.001).
Our results suggest that diminished paraoxonase and arylesterase activity, -SH levels and increased LOOH levels are associated with particular stage, grade and CA-125 level of ovarian cancer.
高密度脂蛋白相关的对氧磷酶和芳基酯酶活性在降低氧化应激中发挥作用，而氧化应激已知会促进癌症发展。本研究的目的是评估新诊断的上皮性卵巢癌患者的血清对氧磷酶和芳基酯酶活性以及脂质过氧化氢（LOOH）水平。
对24例上皮性卵巢癌患者和29例对照者测定血清对氧磷酶和芳基酯酶活性、总游离巯基（-SH）水平和LOOH水平。
与对照组相比，上皮性卵巢癌患者的血清对氧磷酶活性、芳基酯酶活性以及-SH水平显著降低（分别为p = 0.003、p < 0.001和p < 0.001），而LOOH水平显著升高（p < 0.001）。在卵巢癌的分期、分级和CA-125水平与对氧磷酶活性（分别为rho = -0.630，p = 0.001；rho = -0.601，p = 0.002；rho = -0.436，p = 0.033）、芳基酯酶活性（分别为rho = -0.601，p = 0.002；rho = -0.713，p < 0.001；rho = -0.580，p = 0.003）和-SH水平（分别为rho = -0.642，p = 0.001；rho = -0.637，p = 0.001；rho = -0.530，p = 0.008）之间发现显著的负相关。相反，LOOH与卵巢癌的分期、分级和CA-125水平之间存在正相关（rho = 0.565，p = 0.004；rho = 0.479，p = 0.018；rho = 0.642，p = 0.001）。
我们的结果表明，对氧磷酶和芳基酯酶活性降低、-SH水平降低以及LOOH水平升高与卵巢癌的特定分期、分级和CA-125水平相关。
