Department of Biomaterials, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
J Biomed Mater Res B Appl Biomater. 2011 May;97(2):289-98. doi: 10.1002/jbm.b.31814. Epub 2011 Mar 10.
Short-term, experimental studies of partly laser-modified implants with nano-scale surface topographical features have recently shown a considerable increase in the biomechanical anchorage to bone. The aim of this study is to evaluate the biomechanical and bone-bonding ability of partly laser-modified implants compared with machined implants after a healing period of 6 months in a rabbit model. The results showed a 170% increase in removal torque. Histology and scanning electron microscopy demonstrated osseointegration for both implant types, but also revealed a different fracture pattern at the interface and in the bone. Transmission electron microscopy and chemical analysis showed coalescence between mineralized tissue and the nano-structured surface of the laser modified implant. Taken together, the results indicate that nano-structured surfaces promote in vivo long-term bone bonding and interface strength.
近期，针对具有纳米级表面形貌特征的部分激光改性种植体的短期实验研究表明，其与骨的生物力学锚固能力有显著提高。本研究旨在通过兔模型 6 个月的愈合期，评估部分激光改性种植体与机械加工种植体的生物力学和骨结合能力。结果显示，其去除扭矩增加了 170%。组织学和扫描电子显微镜显示两种种植体均实现了骨整合，但也显示出界面和骨内不同的断裂模式。透射电子显微镜和化学分析显示，矿化组织与激光改性种植体的纳米结构表面融合。总之，结果表明纳米结构表面促进了体内长期的骨结合和界面强度。
