[氧化锌纳米颗粒的生物利用度。采用放射性核素指示剂法的研究]

[The bioavailability of zinc oxide nanoparticles. Study using methods of radionuclide indicators].

作者信息

Raspopov R V, Buzulukov Iu P, Marchenkov N S, Solov'ev V Iu, Demin V F, Kalistratova V S, Gmoshinskiĭ I V, Khotimchenko S A

出版信息

Vopr Pitan. 2010;79(6):14-8.

PMID:21395099

Abstract

Zinc oxide nanoparticles labeled with 65Zn were administered once intragastrically to male Wistar rats. The distribution of radionuclide-marker (65Zn) was measured by gamma-spectrometer in tissue samples of animals the organs through 4 hours, 1, 3 and 5 days after administration, and in the wastes of animals through 1 since 5 days. The data obtained demonstrate for the first time the bioavailability of zinc trace element in the form of its oxide nanoparticles.

摘要

将用⁶⁵Zn标记的氧化锌纳米颗粒经胃内一次性给予雄性Wistar大鼠。在给药后4小时、1天、3天和5天，用γ能谱仪测量动物各器官组织样本中放射性核素标记物（⁶⁵Zn）的分布，并在给药后1至5天测量动物排泄物中的分布。所获得的数据首次证明了锌微量元素以其氧化物纳米颗粒形式的生物利用度。