Suppr超能文献

电化学视角下的他莫昔芬生物转化:现状与未来展望。

An electrochemical outlook on tamoxifen biotransformation: current and future prospects.

机构信息

Departamento de Engenharia Química, Instituto Superior de Engenharia do Porto, IPP, 4200-072 Porto, Portugal.

出版信息

Curr Drug Metab. 2011 May;12(4):372-82. doi: 10.2174/138920011795202965.

Abstract

Tamoxifen is a nonsteroidal antiestrogen that is currently and widely used in the treatment of breast cancer in all of its stages, in adjuvant therapy as a long-term suppressant of tumor recurrence and also as a chemopreventive agent in women that are in high risk of developing this type of estrogen-dependent cancer. From a toxicological and (bio)analytical point of view the knowledge of the metabolic pathways of a drug is found to be extremely important. So, in the present work the most important tamoxifen biotransformation steps were reviewed in the light of recent pharmacological data. This overview also includes the current controversy concerning tamoxifen DNA-damaging (genotoxic) versus non-genotoxic mechanisms. A special focus will be given to the putative application of electrochemical methods as a modern and reliable analytical tool for determination of tamoxifen and its metabolites. Moreover, the potential of DNA electrochemical sensors for detection of structural damage to DNA as a basis for toxicity screening is highlighted. Future prospects looking for the importance of developing new analytical methodologies are also discussed.

摘要

他莫昔芬是一种非甾体类抗雌激素药物,目前广泛用于各期乳腺癌的治疗,作为辅助治疗药物,用于长期抑制肿瘤复发,也作为一种化学预防剂用于有发展这种雌激素依赖性癌症风险的妇女。从毒理学和(生物)分析的角度来看,了解药物的代谢途径是非常重要的。因此,在目前的工作中,根据最近的药理学数据,综述了他莫昔芬最重要的生物转化步骤。这一综述还包括了关于他莫昔芬的 DNA 损伤(遗传毒性)与非遗传毒性机制的当前争议。特别关注电化学方法作为一种现代可靠的分析工具,用于测定他莫昔芬及其代谢物的潜在应用。此外,还强调了电化学 DNA 传感器检测 DNA 结构损伤作为毒性筛选基础的潜力。还讨论了寻找开发新分析方法学的重要性的未来前景。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验