Department of Public Health and Health Policy, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
Environ Res. 2011 Apr;111(3):377-87. doi: 10.1016/j.envres.2011.02.005.
An association between exposure to traffic-related air pollution and reduced birth weight has been suggested. However, previous studies have failed to adjust for maternal size, which is an indicator of individual genetic growth potential. Therefore, we evaluated the association of air pollution with birth weight, term low birth weight (term-LBW), and small for gestational age (SGA), with adjustment for maternal size. Individual data were extracted from a database that is maintained by a maternal and perinatal care center in Shizuoka, Japan. We identified liveborn singleton births (n=14,204). Using geocoded residential information, each birth was assigned a number of traffic-based exposure indicators: distance to a major road; distance-weighted traffic density; and estimated concentration of nitrogen dioxide by land use regression. The multivariate adjusted odds ratios and their 95% confidence intervals (CIs) for the associations between exposure indicators and outcomes were then estimated using logistic regression models. Overall, exposure indicators of air pollution showed no clear pattern of association. Although there are many limitations, we did not find clear associations between birth-weight-related outcomes and the three markers of traffic-related air pollution.
已有研究表明，接触与交通相关的空气污染与降低出生体重之间存在关联。然而，先前的研究未能调整母体大小，而母体大小是个体遗传生长潜力的一个指标。因此，我们评估了空气污染与出生体重、足月低出生体重（term-LBW）和小于胎龄儿（SGA）之间的关联，同时调整了母体大小。个体数据从日本静冈县一家母婴保健中心维护的数据库中提取。我们确定了活产单胎分娩（n=14204）。使用地理编码的居住信息，为每个分娩分配了多个基于交通的暴露指标：距主要道路的距离；距离加权交通密度；和基于土地利用回归估计的二氧化氮浓度。然后使用逻辑回归模型估计暴露指标与结果之间关联的多变量调整比值比及其 95%置信区间（CI）。总体而言，空气污染暴露指标与结果之间没有明显的关联模式。尽管存在许多局限性，但我们没有发现与交通相关空气污染的三个标志物与出生体重相关结果之间存在明确的关联。
