Oncology Unit, Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Greece.
Cancer Lett. 2011 May 28;304(2):144-53. doi: 10.1016/j.canlet.2011.02.018.
The aim of this study was to define pre-treatment VEGF, VEGFR1 and VEGFR2 levels in serum and bronchial washing samples of NSCLC patients in order to examine their correlation to survival. Forty patients with histologically confirmed NSCLC were enrolled. The results indicated that circulating VEGF was correlated to T-classification, as were the ratios of VEGF/VEGFR2 in serum and washing. Best chemotherapy response was observed at lower serum and washing VEGF concentrations. Higher VEGF levels in washing were associated with worse overall survival and progression-free survival. Similar were the results at high values of VEGF/VEGFR2 ratio in washing. Multivariate analysis revealed VEGFR2 levels in serum and washing as independent markers for overall survival. In conclusion, washing VEGFR2 levels are correlated to overall survival, whereas serum and washing VEGF levels are predictive of chemotherapy response. These could help recognize NSCLC patients who benefit from an aggressive therapeutic approach.
本研究旨在确定 NSCLC 患者治疗前血清和支气管灌洗液中 VEGF、VEGFR1 和 VEGFR2 的水平，以探讨其与生存的相关性。共纳入 40 例组织学证实的 NSCLC 患者。结果表明，循环 VEGF 与 T 分期相关，血清和灌洗液中 VEGF/VEGFR2 的比值也与 T 分期相关。较低的血清和灌洗液 VEGF 浓度与更好的化疗反应相关。灌洗液中较高的 VEGF 水平与总生存期和无进展生存期较差相关。灌洗液中 VEGF/VEGFR2 比值较高时也有类似的结果。多因素分析显示，血清和灌洗液中的 VEGFR2 水平是总生存期的独立标志物。总之，灌洗液 VEGFR2 水平与总生存期相关，而血清和灌洗液 VEGF 水平可预测化疗反应。这些结果有助于识别从积极治疗方法中获益的 NSCLC 患者。
