Mental Health Service, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA.
Psychiatry Res. 2011 May 30;187(3):324-8. doi: 10.1016/j.psychres.2011.02.011. Epub 2011 Mar 11.
Measures of acoustic startle such as prepulse inhibition (PPI) and startle latency have been found to be impaired in schizophrenia, and are commonly thought to be related to cognitive deficits in this disease. However, findings about the relationship between startle variables and cognitive performance have been equivocal. In this study, we examined correlations between startle measures (baseline startle magnitude, latency, habituation and PPI) and cognitive performance (using the Benton Visual Retention Test, Conner's Continuous Performance Test, California Verbal Learning Test, Finger Tapping Test, and Wisconsin Card Sort Test) in 107 schizophrenia patients and 94 healthy controls. Overall, there was a lack of any significant relationship between these constructs in both populations when correcting for multiple comparisons. This suggests that alterations in startle measures seen in schizophrenia may not reflect elements of information processing that cause cognitive deficits in the disease.
人们发现，诸如条件性惊吓反射抑制（PPI）和惊吓潜伏期等听觉惊吓测量指标在精神分裂症中存在损伤，并且通常被认为与这种疾病的认知缺陷有关。然而，关于惊吓变量与认知表现之间的关系的研究结果却存在争议。在这项研究中，我们检查了 107 名精神分裂症患者和 94 名健康对照者的惊吓测量指标（基础惊吓幅度、潜伏期、习惯化和 PPI）与认知表现（使用本顿视觉保持测验、康纳连续操作测验、加州语言学习测验、手指敲击测验和威斯康星卡片分类测验）之间的相关性。总体而言，在对多重比较进行校正后，这两个群体之间这些结构之间缺乏任何显著的关系。这表明，在精神分裂症中观察到的惊吓测量指标的改变可能并不能反映导致疾病认知缺陷的信息处理要素。
