Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.
Trends Pharmacol Sci. 2011 Apr;32(4):201-5. doi: 10.1016/j.tips.2011.02.003. Epub 2011 Mar 10.
Gastrin, acting through peripheral cholecystokinin (CCK) 2 receptors, is a major hormonal regulator of gastric acid secretion. The effects of gastrin on acid secretion occur both acutely and chronically because gastrin directly stimulates gastric acid secretion and also exerts trophic effects on the enterochromaffin-like and parietal cells that together constitute the acid secretory apparatus of the stomach. Several antagonists that target the CCK2 receptor have been identified and investigated for the treatment of gastroesophageal reflux disease and pancreatic cancer. In this paper, we discuss the contribution of gastrin to these disease pathologies and the data generated to date from clinical studies investigating CCK2 receptor antagonists.
胃泌素通过外周胆囊收缩素（CCK）2 受体发挥作用，是胃酸分泌的主要激素调节剂。胃泌素对胃酸分泌的作用既有急性作用，也有慢性作用，因为胃泌素直接刺激胃酸分泌，还对肠嗜铬样细胞和壁细胞发挥营养作用，而这些细胞共同构成了胃的胃酸分泌装置。已经鉴定出几种针对 CCK2 受体的拮抗剂，并对其进行了研究，以治疗胃食管反流病和胰腺癌。在本文中，我们讨论了胃泌素对这些疾病病理的贡献，以及迄今为止从研究 CCK2 受体拮抗剂的临床研究中获得的数据。
