Beaumesnil M, Chaillou E, Wagner A-C, Rouquette A, Audran M, Giniès J-L
Département de pédiatrie, centre de ressources et de compétences pour mucoviscidose, centre Robert-Debré, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 09, France.
Arch Pediatr. 2011 Apr;18(4):370-5. doi: 10.1016/j.arcped.2011.01.008.
Nutritional status must be closely monitored in cystic fibrosis (CF) patients. This study compared three methods of measuring body composition in CF patients and then examined the relationships between two simple anthropometric markers of nutritional status - tricipital skinfold thickness (TSK) and arm muscular circumference (AMC) - and the results given by each method. Fifty-five patients with CF, 27 females and 28 males, participated in this study. The mean age at the time of the study was 14 ± 5 years, ranging from 4 to 29 years. The four skinfolds (SK) and arm circumference were measured in all patients and fat mass (FM) and AMC were calculated. Fifty patients underwent dual energy x-ray absorptiometry (DEXA) and 38 underwent bioelectrical impedance analysis (BIA). The values for FM as calculated by the three methods were highly correlated, as were the values for lean body mass (LM) (p<0.001). The LM assessed by anthropometry was overestimated by 8 ± 4% compared with DEXA and by 6 ± 7% compared with BIA. BIA overestimated LM by 4 ± 6% compared with DEXA (p<0.001). The LM values measured by SK, DEXA, and BIA were highly correlated with AMC (p<0.001) and FM calculated using these three techniques were highly correlated with TSK (p<0.001). The measurement of TSK and AMC are simple and rapid ways to evaluate body composition. The excellent correlation between the three methods used to measure body composition suggests that they are valid for use in patients with CF, but the results were not identical. The measurement from each technique must be interpreted according to its own norms and comparisons can only be made if the same technique is used in the same patient.
囊性纤维化（CF）患者的营养状况必须密切监测。本研究比较了三种测量CF患者身体成分的方法，然后研究了两种简单的营养状况人体测量指标——三头肌皮褶厚度（TSK）和上臂肌肉周长（AMC）——与每种方法所得结果之间的关系。55例CF患者参与了本研究，其中27例女性，28例男性。研究时的平均年龄为14±5岁，范围为4至29岁。对所有患者测量了四处皮褶（SK）和上臂围，并计算了脂肪量（FM）和AMC。50例患者接受了双能X线吸收法（DEXA）检查，38例接受了生物电阻抗分析（BIA）。三种方法计算得到的FM值高度相关，瘦体重（LM）值也是如此（p<0.001）。与DEXA相比，通过人体测量评估的LM高估了8±4%，与BIA相比高估了6±7%。与DEXA相比，BIA高估LM 4±6%（p<0.001）。通过SK、DEXA和BIA测量的LM值与AMC高度相关（p<0.001），使用这三种技术计算得到的FM与TSK高度相关（p<0.001）。测量TSK和AMC是评估身体成分的简单快速方法。用于测量身体成分的三种方法之间的良好相关性表明它们可有效用于CF患者，但结果并不完全相同。每种技术的测量结果必须根据其自身标准进行解释，只有在同一患者中使用相同技术时才能进行比较。
