School of Biotechnology, Banaras Hindu University, Varanasi-221 005, U.P., India.
Toxicol Appl Pharmacol. 2011 May 1;252(3):298-306. doi: 10.1016/j.taap.2011.03.002. Epub 2011 Mar 11.
Using a murine model of a T cell lymphoma, in the present study, we report that tumor growth retarding action of curcumin involves modulation of some crucial parameters of tumor microenvironment regulating tumor progression. Curcumin-administration to tumor-bearing host caused an altered pH regulation in tumor cells associated with alteration in expression of cell survival and apoptosis regulatory proteins and genes. Nevertheless, an alteration was also observed in biophysical parameters of tumor microenvironment responsible for modulation of tumor growth pertaining to hypoxia, tumor acidosis, and glucose metabolism. The study thus sheds new light with respect to the antineoplastic action of curcumin against a tumor-bearing host with progressively growing tumor of hematological origin. This will help in optimizing application of the drug and anticancer research and therapy.
在本研究中，我们使用 T 细胞淋巴瘤的小鼠模型报告姜黄素的肿瘤生长抑制作用涉及调节肿瘤微环境的一些关键参数，这些参数调节肿瘤的进展。姜黄素给药给荷瘤宿主导致肿瘤细胞中 pH 调节的改变，与细胞存活和凋亡调节蛋白和基因的表达改变相关。然而，还观察到与缺氧、肿瘤酸中毒和葡萄糖代谢有关的肿瘤微环境的生物物理参数的改变，这些改变与肿瘤生长的调节有关。因此，这项研究为姜黄素针对具有进行性生长的血液来源肿瘤的荷瘤宿主的抗肿瘤作用提供了新的认识。这将有助于优化药物的应用以及癌症研究和治疗。
