el Hag I A, Roos G, Jönsson P E, Stenram U
Department of Pathology, University Hospital, Lund, Sweden.
Anticancer Res. 1990 Jan-Feb;10(1):29-32.
Rats were inoculated subcutaneously into both flanks with a transplantable adenocarcinoma of the colon. They were treated intravenously with either 5-FUrd (5-fluorouridine) or 5-FdUrd (5-fluoro-2'-deoxyuridine) with or without addition of dipyridamole 20 and 30 min later, respectively, for 3 consecutive days. Dipyridamole improved the antitumor activity of 5-FUrd but decreased that of 5-FdUrd.
将可移植的结肠腺癌皮下接种到大鼠双侧胁腹。分别在20分钟和30分钟后，给大鼠静脉注射5-氟尿苷（5-FUrd）或5-氟-2'-脱氧尿苷（5-FdUrd），加或不加双嘧达莫，连续3天。双嘧达莫增强了5-FUrd的抗肿瘤活性，但降低了5-FdUrd的抗肿瘤活性。
