Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
Cancer Cell. 2011 Mar 8;19(3):295-7. doi: 10.1016/j.ccr.2011.02.018.
Malignant gliomas are characterized by accumulated aberrations affecting TP53, PTEN, and RB1 signaling. In this issue, Chow et al. discover that combinatorial loss of these tumor suppressors in mice induces gliomas with unexpected degrees of similarity to human pathologic, genomic, and expression subclasses recently revealed by large-scale genomic studies.
恶性神经胶质瘤的特征是积累了影响 TP53、PTEN 和 RB1 信号的异常。在本期杂志中，Chow 等人发现，这些肿瘤抑制因子在小鼠中的联合缺失会导致胶质瘤，其在病理、基因组和表达亚类方面与最近大规模基因组研究揭示的人类肿瘤具有出人意料的相似性。
