Faubert G M, Meerovitch E, McLaughlin J
Am J Trop Med Hyg. 1978 Sep;27(5):892-6. doi: 10.4269/ajtmh.1978.27.892.
Auto-antibodies against normal human liver have been detected in the sera of humans with highly positive indirect hemagglutination (IHA) amebiasis titers and with clinically-proven amebic liver abscess. Sera of amebiasis patients and rabbits immunized with killed Entamoeba histolytica were tested for anti-amebic antibodies by the IHA test and for auto-antibodies by the complement fixation test, using the antigens prepared from extracts of human liver and rabbit liver. A direct correlation was found to exist between high anti-Entamoeba antibody titers and the presence of anti-liver antibody in the serum. It is proposed that, in addition to direct parasite damage to host tissue, immunological damage could result from the attachment of circulating antigen to the cell surfaces of host tissues such as the liver.
在间接血凝（IHA）滴度呈强阳性且经临床证实患有阿米巴肝脓肿的人类血清中，已检测到针对正常人肝脏的自身抗体。使用从人肝和兔肝提取物制备的抗原，通过IHA试验检测阿米巴病患者血清和用灭活溶组织内阿米巴免疫的兔血清中的抗阿米巴抗体，并通过补体结合试验检测自身抗体。发现血清中高抗溶组织内阿米巴抗体滴度与抗肝抗体的存在之间存在直接相关性。有人提出，除了寄生虫对宿主组织的直接损害外，循环抗原附着于肝脏等宿主组织的细胞表面可能导致免疫损伤。
