Gutsov A A
Kardiologiia. 1990 Jan;30(1):66-8.
Balloon dilatation was used to explore the strength of the left ventricular wall in rats. The rupture pressure of the left ventricle was 645 +/- 22 mm Hg and that of the right ventricle was 247 +/- 15 mm Hg in intact animals. Left ventricular hypertrophy induced by 50% ascending aortic stenosis increased rupture pressure proportionally to the degree of hypertrophy. In transmural myocardial infarction occupying 40-55% of the left ventricular wall volume, the rupture pressure within 10 days of myocardial infarction was the same as that in the intact myocardium. Following 24 hours of ischemia, myocardial reperfusion produced no effects, but after 2 or 4 hours of ischemia it reduced the strength of the heart wall by 50%. It was concluded that early thrombolytic therapy might be a risk factor for cardiac rupture in myocardial infarction.
采用球囊扩张法研究大鼠左心室壁的强度。在完整动物中，左心室的破裂压力为645±22 mmHg，右心室的破裂压力为247±15 mmHg。50%升主动脉狭窄所致的左心室肥厚使破裂压力与肥厚程度成比例增加。在占左心室壁体积40 - 55%的透壁性心肌梗死中，心肌梗死后10天内的破裂压力与完整心肌相同。缺血24小时后，心肌再灌注无影响，但缺血2或4小时后，心脏壁强度降低50%。得出的结论是，早期溶栓治疗可能是心肌梗死心脏破裂的一个危险因素。
