Instituto de Investigación Médica M. y M. Ferreyra (INIMEC-CONICET), Córdoba, C.P 5000, Argentina.
Dev Psychobiol. 2011 Apr;53(3):234-45. doi: 10.1002/dev.20516. Epub 2010 Nov 17.
There is a scarcity of research on ethanol affinity in alcohol-preferring (P) rats before weaning and it is unknown if neonate P rats exhibit ethanol intake preferences comparable to those observed in adult P rats. This study examined ethanol intake in P and alcohol-nonpreferring (NP) rats 3 hr after birth (Experiment 1, surrogate nipple test), at postnatal days (PD) 8, 12, and 18 (Experiment 2, consumption from the floor procedure) and at adolescence (Experiment 3, two-bottle choice test at PD32). The high-preference genotype was readily expressed 3 hr after birth. P neonates drank twice as much ethanol as their NP counterparts. This heightened ethanol preference transiently reversed at P8, reemerged as weaning approached (P18) and was fully expressed during adolescence. These results help to clarify the ontogeny of genetic predisposition for ethanol. Genetic predisposition for higher ethanol intake in P than in NP rats seems to be present immediately following birth.
在断奶前，对酒精偏好（P）大鼠的乙醇亲和力的研究很少，并且尚不清楚新生 P 大鼠是否表现出与成年 P 大鼠相似的乙醇摄入偏好。本研究在出生后 3 小时（实验 1，替代奶嘴测试）、出生后第 8、12 和 18 天（实验 2，从地板上消耗的程序）和青春期（实验 3，PD32 时的双瓶选择测试）检查了 P 和非酒精偏好（NP）大鼠的乙醇摄入量。高偏好基因型在出生后 3 小时即可轻松表达。P 新生儿的乙醇摄入量是其 NP 对应物的两倍。这种较高的乙醇偏好性在 P8 时短暂逆转，接近断奶时（P18）再次出现，并在青春期完全表达。这些结果有助于阐明乙醇遗传易感性的个体发生。与 NP 大鼠相比，P 大鼠对更高乙醇摄入的遗传易感性似乎在出生后立即存在。
