Department of Anesthesiology, Fatih University Faculty of Medicine, Ankara, Turkey.
Ren Fail. 2011;33(3):280-4. doi: 10.3109/0886022X.2011.560502.
The aim of this prospective randomized, double-blinded study was to evaluate the effect of fentanyl addition to articaine on the duration of sensory as well as motor blocks, and the duration of analgesia during hemodialysis fistula creation under ultrasound-guided axillary block. Fifty patients were randomly allocated to two groups, an articaine group (A), receiving 40 mL of articaine HCI (20 mg/mL) with 2 mL of isotonic sodium chloride solution, and an articaine-fentanyl group (AF), receiving 40 mL of articaine HCI (20 mg/mL) with 2 mL (100 µg) of fentanyl. The onset as well as the duration of sensory and motor blocks, the time necessary for first analgesic administration, the hemodynamic parameters, and the side effects were recorded. Three patients in Group A and two patients in Group AF due to incomplete block were excluded from the study. The duration of sensory and motor blocks was significantly longer in the AF group than in the A group. The first time for analgesic need was also significantly longer in group AF (363 ± 134 min) than in group A (244 ± 84 min) (p = 0.001). The addition of fentanyl did not improve the onset of sensory and motor block times. Hemodynamic parameters were similar in the two groups. In conclusion, the addition of fentanyl to articaine in axillary block prolongs the duration of sensory and motor blocks, as well as the time of first analgesic requirement.
本前瞻性随机、双盲研究旨在评估在超声引导下腋路阻滞下进行血液透析造瘘术中，盐酸阿替卡因中添加芬太尼对感觉和运动阻滞持续时间以及镇痛持续时间的影响。将 50 名患者随机分为两组，阿替卡因组（A 组）接受 40 毫升盐酸阿替卡因（20 毫克/毫升）加 2 毫升等渗氯化钠溶液，阿替卡因-芬太尼组（AF 组）接受 40 毫升盐酸阿替卡因（20 毫克/毫升）加 2 毫升（100μg）芬太尼。记录感觉和运动阻滞的起始和持续时间、首次镇痛给药所需的时间、血流动力学参数和副作用。由于阻滞不完全，A 组有 3 例患者和 AF 组有 2 例患者被排除在研究之外。AF 组的感觉和运动阻滞持续时间明显长于 A 组。AF 组（363±134 分钟）首次需要镇痛的时间也明显长于 A 组（244±84 分钟）（p=0.001）。添加芬太尼并没有改善感觉和运动阻滞的起始时间。两组的血流动力学参数相似。总之，在腋路阻滞中添加芬太尼到阿替卡因会延长感觉和运动阻滞的持续时间以及首次需要镇痛的时间。
