Department of Cardiology, La-Cavale-Blanche Hospital, Brest University Hospital, Boulevard T.-Prigent, 29609 Brest Cedex, France.
Arch Cardiovasc Dis. 2011 Feb;104(2):77-83. doi: 10.1016/j.acvd.2010.11.008. Epub 2011 Jan 22.
Extracranial internal carotid artery stenosis is a risk factor for perioperative stroke in patients undergoing coronary artery bypass surgery (CAB). Although selective and non-selective methods of preoperative carotid screening have been advocated, it remains unclear if this screening is clinically relevant.
To test whether selective carotid screening is as effective as non-selective screening in detecting significant carotid disease.
The case records of patients consecutively undergoing CAB were reviewed. Patients were stratified retrospectively into high- or low-risk groups according to risk factors for significant carotid stenosis and perioperative stroke: peripheral vascular disease (PVD), carotid bruit, diabetes mellitus, age >70 years and/or history of cerebrovascular disease. Prevalence of carotid stenosis detected by ultrasonography, surgical management and perioperative stroke rates were determined in each group.
Overall, 205 consecutive patients underwent preoperative carotid screening. The prevalence of significant carotid stenosis was 5.8%. Univariate analysis confirmed that PVD (P=0.005), carotid bruit (P=0.003) and diabetes mellitus (P=0.05) were significant risk factors for stenosis. Carotid stenosis was a risk factor for stroke (P=0.03). Prevalence of carotid stenosis was higher in the high-risk group (9.1%) than the low-risk group (1.2%) (P<0.05). All concomitant or staged carotid endarterectomies/CAB (5/205) and all patients who had perioperative strokes (5/205) were in the high-risk group (P=0.01).
In our cohort, selective screening of patients aged >70 years, with carotid bruit, a history of cerebrovascular disease, diabetes mellitus or PVD would have reduced the screening load by 40%, with trivial impact on surgical management or neurological outcomes.
颅外颈内动脉狭窄是冠状动脉旁路移植术(CAB)患者围手术期卒中的危险因素。虽然提倡选择性和非选择性的术前颈动脉筛查,但目前尚不清楚这种筛查是否具有临床意义。
检验选择性颈动脉筛查在检测显著颈动脉疾病方面是否与非选择性筛查同样有效。
回顾性分析连续接受 CAB 的患者的病历。根据显著颈动脉狭窄和围手术期卒中的危险因素(外周血管疾病[PVD]、颈动脉杂音、糖尿病、年龄>70 岁和/或脑血管病史),将患者分为高风险或低风险组。确定每组患者的超声检查发现的颈动脉狭窄率、手术处理方法和围手术期卒中发生率。
共有 205 例连续患者接受了术前颈动脉筛查。显著颈动脉狭窄的患病率为 5.8%。单因素分析证实,PVD(P=0.005)、颈动脉杂音(P=0.003)和糖尿病(P=0.05)是狭窄的显著危险因素。颈动脉狭窄是卒中的危险因素(P=0.03)。高风险组(9.1%)的颈动脉狭窄患病率高于低风险组(1.2%)(P<0.05)。所有同期或分期颈动脉内膜切除术/CAB(5/205)和所有发生围手术期卒中的患者(5/205)均在高风险组(P=0.01)。
在我们的队列中,对年龄>70 岁、有颈动脉杂音、脑血管病史、糖尿病或 PVD 的患者进行选择性筛查,可将筛查负荷减少 40%,而对手术管理或神经结局的影响微乎其微。