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评估冠状动脉旁路移植术前颈动脉狭窄和下肢周围缺血:一项非随机临床试验。

Assessment of carotid artery stenosis and lower limb peripheral ischemia before coronary artery bypass grafting operations: a non-randomized clinical trial.

机构信息

Department of Cardiothoracic Surgery, Ain Shams University, Cairo, 11355, Egypt.

Department of Anesthesiology, Ain Shams University, Cairo, Egypt.

出版信息

J Cardiothorac Surg. 2020 Sep 29;15(1):283. doi: 10.1186/s13019-020-01340-7.

Abstract

BACKGROUND

Atherosclerosis is a systemic disease affecting the coronary, carotid, and lower limb arteries. Cerebrovascular accidents and lower limb ischemia are devastating postoperative complications. We aimed to evaluate the role of non-selective routine arterial duplex scanning in patients undergoing coronary artery bypass grafting (CABG).

METHODS

This non-randomized clinical trial included 360 patients scheduled for elective isolated CABG who were divided into two groups: low-risk (n = 180) and high-risk (n = 180). Both groups underwent preoperative carotid and lower limb ultrasound screening for associated arteriopathy.

RESULTS

16 (8.9%) patients and 22 (12.2%) patients showed ≥70% carotid artery stenosis while 11 patients (6.1%) and 20 patients (11.1%) showed ≥50% lower limb arterial stenosis in the low-risk group and the high-risk group, respectively; though the difference was not statistically significant in both the cases (p > 0.1).

CONCLUSION

Routine preoperative peripheral arterial screening by sonography is a feasible and effective strategy to avoid unnecessary post CABG complications.

TRIAL REGISTRATION

NCT03516929 , Registered in 24 th of April 2018.

摘要

背景

动脉粥样硬化是一种全身性疾病,可影响冠状动脉、颈动脉和下肢动脉。脑血管意外和下肢缺血是术后毁灭性的并发症。我们旨在评估非选择性常规动脉双重扫描在冠状动脉旁路移植术(CABG)患者中的作用。

方法

本非随机临床试验纳入了 360 例拟行择期单纯 CABG 的患者,将其分为低危组(n=180)和高危组(n=180)。两组患者均接受术前颈动脉和下肢超声筛查,以发现相关动脉疾病。

结果

在低危组和高危组中,分别有 16 名(8.9%)和 22 名(12.2%)患者颈动脉狭窄≥70%,11 名(6.1%)和 20 名(11.1%)患者下肢动脉狭窄≥50%;但在这两种情况下,差异均无统计学意义(p>0.1)。

结论

术前常规外周动脉超声筛查是避免 CABG 后并发症的可行且有效的策略。

试验注册

NCT03516929,于 2018 年 4 月 24 日注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe2f/7525944/73a06fe8479a/13019_2020_1340_Fig1_HTML.jpg

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