慢性吗啡戒断过程中 5-HT(1A)受体功能的顺序和相反改变。
Sequential and opposing alterations of 5-HT(1A) receptor function during withdrawal from chronic morphine.
机构信息
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université de Strasbourg, 1 Rue Laurent Fries, 67404 Illkirch, France.
出版信息
Eur Neuropsychopharmacol. 2011 Nov;21(11):835-40. doi: 10.1016/j.euroneuro.2011.02.002. Epub 2011 Mar 12.
Abstract
Addiction is a brain chronic relapsing disorder associated with emotional distress. The serotonergic system and especially the 5-HT(1A) receptor crucially regulate emotional behaviors both in humans and rodents. Using [(35)S]GTPγS autoradiography in mice, we show that 5-HT(1A) receptor function is enhanced by chronic morphine treatment in the medial prefrontal cortex, and decreased in dorsal raphe nucleus one week later, two regions involved in emotional processing. These molecular adaptations could contribute to the development of emotional disorders experienced by former opiate addicts.
摘要
成瘾是一种与情绪困扰相关的大脑慢性复发性疾病。5-羟色胺能系统，尤其是 5-HT(1A)受体，在人类和啮齿动物中都对情绪行为起着至关重要的调节作用。我们利用[(35)S]GTPγS 放射自显影技术在小鼠中发现，5-HT(1A)受体功能在慢性吗啡处理后增强，而在一周后即出现下降，这两个区域都与情绪处理有关。这些分子适应可能导致曾经的阿片类成瘾者出现情绪障碍。
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