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干预措施能否改善婴儿睡眠质量,从而降低 6 岁时超重的风险?一项随机试验的随访研究。

Does an intervention that improves infant sleep also improve overweight at age 6? Follow-up of a randomised trial.

机构信息

Centre for Community Child Health, Royal Children's Hospital, Flemington Road, Parkville, VIC 3052, Australia.

出版信息

Arch Dis Child. 2011 Jun;96(6):526-32. doi: 10.1136/adc.2010.196832. Epub 2011 Mar 14.

DOI:10.1136/adc.2010.196832
PMID:21402578
Abstract

OBJECTIVE

Short sleep duration may contribute to childhood obesity. Amenable to intervention, sleep thus provides a potential path for prevention. The authors aimed to determine the impact of a behavioural intervention that successfully reduced parent-reported infant sleep problems on adiposity at age 6.

DESIGN

5-year follow-up of a previously reported population-based cluster randomised trial. Participant allocation was concealed to researchers and data collection blinded.

SETTING

Recruitment from well-child centres in Melbourne, Australia.

PARTICIPANTS

328 children (174 intervention) with parent-reported sleep problems at age 7-8 months drawn from 49 centres (clusters).

INTERVENTION

Behavioural sleep strategies delivered over one to three structured individual nurse consultations from 8 to 10 months, versus usual care. MAIN OUTCOMES AT AGE 6 YEARS: Body mass index (BMI) z-score, percentage overweight/obese and waist circumference.

ANALYSES

Intention-to-treat regression analyses adjusted for potential confounders.

RESULTS

Anthropometric data were available for 193 children (59% retention) at age 6. There was no evidence of a difference between intervention (N=101) and control (N=92) children for BMI z-score (adjusted mean difference 0.2, 95% CI -0.1 to 0.4), overweight/obese status (20% vs 17%; adjusted OR 1.4, 95% CI 0.7 to 2.8) and waist circumference (adjusted mean difference -0.3, 95% CI -1.6 to 1.1). In posthoc analyses, neither infant nor childhood sleep duration were associated with anthropometric outcomes.

CONCLUSIONS

A brief infant sleep intervention did not reduce overweight/obesity at 6 years. Population-based primary care sleep services seem unlikely to reduce the early childhood obesity epidemic.

摘要

目的

睡眠时间短可能导致儿童肥胖。可干预的睡眠为预防肥胖提供了一个潜在途径。作者旨在确定一项成功减少家长报告的婴儿睡眠问题的行为干预措施对 6 岁时肥胖的影响。

设计

先前报道的基于人群的集群随机试验的 5 年随访。研究人员对参与者的分配情况保密,数据收集情况设盲。

地点

澳大利亚墨尔本的儿童保健中心招募。

参与者

328 名(174 名干预组)有家长报告的 7-8 月龄婴儿睡眠问题,来自 49 个中心(集群)。

干预

从 8 至 10 个月,通过 1 至 3 次结构化的个别护士咨询提供行为睡眠策略,与常规护理相比。

主要结局指标

6 岁时的体重指数(BMI)z 评分、超重/肥胖百分比和腰围。

分析

意向治疗回归分析调整了潜在混杂因素。

结果

193 名儿童(59%的保留率)在 6 岁时可获得人体测量数据。干预组(N=101)和对照组(N=92)儿童的 BMI z 评分(调整后的平均差异 0.2,95%CI -0.1 至 0.4)、超重/肥胖状态(20%比 17%;调整后的 OR 1.4,95%CI 0.7 至 2.8)和腰围(调整后的平均差异 -0.3,95%CI -1.6 至 1.1)之间没有证据表明存在差异。在事后分析中,婴儿期和儿童期的睡眠时间均与人体测量结果无关。

结论

短暂的婴儿睡眠干预并不能降低 6 岁时的超重/肥胖率。基于人群的初级保健睡眠服务似乎不太可能减少儿童早期肥胖的流行。

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