Bonneterre J
Centre Oscar-Lambret, Lille, France.
Bull Cancer. 1990;77(3):267-74.
Most pancreatic cancers cannot be resected at the time of diagnosis. The efficiency of chemotherapy is poor and does not seem to modify the spontaneous evolution of the tumor. 5FU alone, whatever the regimen, is the most active drug leading to a response rate of 20-30%; polychemotherapy protocols--particularly FAM and SMF--are not any more active; survival of patients does not differ when using mono- or polychemotherapy. Patients with pancreatic cancer that cannot be resected should be treated by 5FU monochemotherapy when not entering a clinical trial.
大多数胰腺癌在诊断时无法进行切除。化疗效果不佳，似乎无法改变肿瘤的自然发展进程。无论采用何种方案，单独使用5-氟尿嘧啶（5FU）是最有效的药物，缓解率为20%-30%；联合化疗方案——尤其是FAM和SMF——并不更具活性；单药化疗和联合化疗患者的生存率并无差异。无法切除的胰腺癌患者在不参加临床试验时应接受5FU单药化疗。
