Perry Daniel, Sang Allison, Yin Yiming, Zheng Ying-Yi, Morel Laurence
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.
J Biomed Biotechnol. 2011;2011:271694. doi: 10.1155/2011/271694. Epub 2011 Feb 14.
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous mouse models of lupus have led to identification of numerous susceptibility loci from which several candidate genes have emerged. Meanwhile, induced models of lupus have provided insight into the role of environmental factors in lupus pathogenesis as well as provided a better understanding of cellular mechanisms involved in the onset and progression of disease. The SLE-like phenotypes present in these models have also served to screen numerous potential SLE therapies. Due to the complex nature of SLE, it is necessary to understand the effect specific targeted therapies have on immune homeostasis. Furthermore, knowledge gained from mouse models will provide novel therapy targets for the treatment of SLE.
系统性红斑狼疮（SLE）是一种多因素自身免疫性疾病。对多种狼疮小鼠模型的研究为SLE的病因提供了线索。狼疮的自发小鼠模型已导致鉴定出众多易感基因座，从中出现了几个候选基因。同时，狼疮的诱导模型为环境因素在狼疮发病机制中的作用提供了见解，并有助于更好地理解疾病发生和发展过程中涉及的细胞机制。这些模型中出现的SLE样表型也用于筛选众多潜在的SLE治疗方法。由于SLE的复杂性，有必要了解特定靶向治疗对免疫稳态的影响。此外，从小鼠模型中获得的知识将为SLE的治疗提供新的治疗靶点。
