Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.
Bull Environ Contam Toxicol. 2011 Apr;86(4):389-93. doi: 10.1007/s00128-011-0235-x. Epub 2011 Mar 15.
The toxic effects of water-soluble fraction (WSF) of crude oil (API27, Petrobras Campos Basin, Brazil) were evaluated during the early life stages of zebrafish, as well as its biotransformation in juvenile fish. Embryonic development was studied during 96 h. Reduced heartbeat rate, weak pigmentation, tail defects, and embryo mortality were observed for all of the tested concentrations of the WSF. Activities of the biotransformation enzymes were induced at the highest concentrations, showing that these enzymes played a role in its elimination. As shown in this study the crude oil WSF altered the normal embryonic development of fish.
水溶性馏分（WSF）的毒性作用评价了石油（API27，巴西坎波斯盆地）在斑马鱼的早期生命阶段，以及其在幼鱼中的生物转化。胚胎发育研究了 96 小时。心跳率降低，色素减退，尾巴缺陷和胚胎死亡率观察到的所有测试浓度的 WSF。生物转化酶的活性在最高浓度下被诱导，表明这些酶在其消除中起作用。如本研究所示，原油 WSF 改变了鱼类正常的胚胎发育。
