King D T, Cihak R W, Luther P K, Gurevitch A W, Hirose F M
Arch Dermatol. 1978 Nov;114(11):1681-3.
Malignant neoplasms of the mucosa and minor salivary glands of the paranasal sinuses may involve the skin by direct extension. When a tumor appears on the overlying skin, these sinuses should be considered as a possible site of origin. Adenoid cystic carcinoma of the paranasal sinuses arise from minor salivary glands. They can infiltrate overlying skin and easily be confused with a primary cutaneous adenoid cystic carcinoma. Malignant melanomas of the paranasal sinuses are clinically very aggressive. They are often amelanotic, and this may lead to an incorrect histopathologic diagnosis. Hence, physical and radiological examination of the nose, mouth, and paranasal sinuses should be performed whenever a tumor appears in the overlying skin that does not have a clear cutaneous origin or whenever the primary site of a metastatic malignant melanoma is unknown.
鼻窦黏膜及小唾液腺的恶性肿瘤可通过直接蔓延累及皮肤。当肿瘤出现在覆盖的皮肤上时，应考虑这些鼻窦为可能的起源部位。鼻窦腺样囊性癌起源于小唾液腺。它们可浸润覆盖的皮肤，且容易与原发性皮肤腺样囊性癌相混淆。鼻窦恶性黑色素瘤在临床上极具侵袭性。它们通常无色素沉着，这可能导致组织病理学诊断错误。因此，每当覆盖皮肤出现无明确皮肤起源的肿瘤或转移性恶性黑色素瘤的原发部位不明时，均应进行鼻、口及鼻窦的体格检查和影像学检查。
