[手术治疗的大细胞神经内分泌癌的预后]

[Prognosis of surgically treated large cell neuroendocrine carcinoma].

作者信息

Matsuura Natsumi, Nakashima Nariyasu, Igai Hitoshi, Tarumi Shintarou, Chang Sung-Soo, Misaki Noriyuki, Liu Dage, Go Tetsuhiko, Ishikawa Shinya, Huang Cheng-Long, Yokomise Hiroyasu

机构信息

Department of General Thoracic, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.

出版信息

Kyobu Geka. 2011 Mar;64(3):187-90.

PMID:21404553

Abstract

Large cell neuroendocrine carcinoma (LCNEC) is a relatively rare tumor in malignant lung neoplasms. The prognosis of LCNEC is poor and there is no consensus on the treatment for LCNEC. We report our retrospective assessment of 11 patients of LCNEC from 1999 to 2008. Three of 11 patients had malignant exudate at thoracotomy. Seven patients received limited resection. There was a recurrence even after complete surgical resection in its early stage. Four patients received platinum-based chemotherapy for adjuvant therapy or recurrence. The response to platinum-based chemotherapy was relatively good and may be comparable to that of small cell lung cancer. The overall 5-year survival rate was 30.3%. Pulmonary LCNEC represents an aggressive tumor and multimodal treatment is required.

摘要

大细胞神经内分泌癌（LCNEC）是恶性肺肿瘤中一种相对罕见的肿瘤。LCNEC的预后较差，对于LCNEC的治疗尚无共识。我们报告了1999年至2008年对11例LCNEC患者的回顾性评估。11例患者中有3例在开胸手术时有恶性胸腔积液。7例患者接受了局限性切除。即使在早期进行了完整的手术切除后仍有复发。4例患者接受了铂类化疗作为辅助治疗或复发后的治疗。对铂类化疗的反应相对较好，可能与小细胞肺癌相当。总体5年生存率为30.3%。肺LCNEC是一种侵袭性肿瘤，需要多模式治疗。