造血细胞输注治疗核灾难受害者：切尔诺贝利事故的新数据。
Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident.
机构信息
Institute of Clinical Radiology, Duke University Medical Center, Durham, NC, USA.
出版信息
Int J Radiat Biol. 2011 Aug;87(8):846-50. doi: 10.3109/09553002.2011.560995. Epub 2011 Mar 16.
PURPOSE
To present previously unavailable data on the use of stem cell administration to aid recovery of victims of the Chernobyl disaster. On 26 April 1986, an accident at Unit 4 of the Chernobyl Nuclear Power Plant took place during the planned test of one of the safety systems. The diagnosis of acute radiation syndrome (ARS) was confirmed in 134 individuals exposed to high levels of radiation. There were nine patients heretofore unreported in the scientific literature who underwent intraosseous injections of allogeneic bone marrow cells in Kyiv.
CONCLUSIONS
Transplantation was associated with significantly shortened time to recovery of granulocyte and platelet counts in these patients. While current guidelines would certainly include the use of cytokines, these data provide an indication of the effectiveness of stem cell transplant to treat victims of radiation exposure.
目的
介绍此前未曾公开的数据，说明使用干细胞疗法来帮助切尔诺贝利灾难的受害者康复。1986 年 4 月 26 日，切尔诺贝利核电站 4 号机组在计划测试其中一个安全系统时发生事故。在 134 名接触高强度辐射的人中，确诊为急性辐射综合征（ARS）。基辅有 9 名此前在科学文献中未报道过的患者接受了同种异体骨髓细胞骨内注射。
结论
与其他疗法相比，这些患者接受移植后，粒细胞和血小板计数恢复时间明显缩短。虽然目前的指南肯定会包括细胞因子的使用，但这些数据表明，干细胞移植对于治疗辐射暴露的受害者是有效的。
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