The Binding Site, Birmingham, UK.
Nephrol Dial Transplant. 2011 Apr;26(4):1438. doi: 10.1093/ndt/gfr019. Epub 2011 Mar 15.
Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.
高截留量血液透析清除游离轻链（FLC）已被描述为治疗多发性骨髓瘤合并严重肾衰竭患者的辅助治疗方法。本文报告的两例患者是首例该治疗未能清除 FLC 的患者。在这两例患者的血清中，通过排阻色谱法鉴定出了分子量超过透析器截留分子量的大 FLC 聚集体。临床医生应认识到 FLC 聚集体是这种新方法未能清除 FLC 的原因。
