Karr Jeffrey C, Lauretta Joseph, Keriazes Georgia
Lakeland Regional Medical Center, Lakeland,FL 33813, USA.
J Am Podiatr Med Assoc. 2011 Mar-Apr;101(2):146-52. doi: 10.7547/1010146.
Several absorbable and nonabsorbable antibiotic carrier systems are available in the adjunctive surgical management of osteomyelitis of the foot, ankle, and lower leg. These carrier systems have significant limitations regarding which antibiotics can be successfully incorporated into the carrier vehicle. The calcium sulfate and hydroxyapatite Cerament Bone Void Filler is a biocompatible, absorbable ceramic bone void filler that can successfully deliver multiple heat-stable and heat-unstable antibiotics that have not been generally used before with antibiotic beads in treating musculoskeletal infections.
Cerament Bone Void Filler discs with the antibiotics rifampin, vancomycin, tobramycin, cefazolin, cefepime hydrochloride, vancomycin-tobramycin, piperacillin-tazobactam, ceftazidime, and ticarcillin-clavulanate were tested in vitro against methicillin-resistant Staphylococcus aureus.
The zones of inhibition for the Cerament Bone Void Filler antibiotic discs plated against Staphylococcus aureus obtained were 33% to 222% greater than the minimum zones of inhibition breakpoints for bacteria susceptibility as defined by the standard set by the Clinical and Laboratory Standards Institute. Cerament Bone Void Filler discs with the antibiotics plated against Pseudomonas aeruginosa produced zones of inhibition of 93% to 200% greater than the minimum zones of inhibition breakpoints for bacteria susceptibility as defined by the standard set by the Clinical and Laboratory Standards Institute.
The calcium sulfate and hydroxyapatite Cerament Bone Void Filler was an excellent carrier vehicle for multiple antibiotics creating in vitro significant zones of inhibition, thus demonstrating susceptibility against Staphylococcus aureus and Pseudomonas aeruginosa, which holds tremendous promise in treating osteomyeilits.
在足、踝及小腿骨髓炎的辅助手术治疗中，有几种可吸收和不可吸收的抗生素载体系统可供使用。这些载体系统在可成功纳入载体的抗生素种类方面存在显著局限性。硫酸钙和羟基磷灰石Cerament骨缺损填充剂是一种生物相容性、可吸收的陶瓷骨缺损填充剂，它能够成功递送多种热稳定和热不稳定的抗生素，这些抗生素以前一般未与抗生素珠一起用于治疗肌肉骨骼感染。
将含有利福平、万古霉素、妥布霉素、头孢唑林、盐酸头孢吡肟、万古霉素-妥布霉素、哌拉西林-他唑巴坦、头孢他啶和替卡西林-克拉维酸的Cerament骨缺损填充剂圆盘在体外针对耐甲氧西林金黄色葡萄球菌进行测试。
所获得的针对金黄色葡萄球菌接种的Cerament骨缺损填充剂抗生素圆盘的抑菌圈比临床和实验室标准协会制定的标准所定义的细菌敏感性最小抑菌圈断点大33%至222%。针对铜绿假单胞菌接种的含有抗生素的Cerament骨缺损填充剂圆盘产生的抑菌圈比临床和实验室标准协会制定的标准所定义的细菌敏感性最小抑菌圈断点大93%至200%。
硫酸钙和羟基磷灰石Cerament骨缺损填充剂是多种抗生素的优良载体，在体外产生显著的抑菌圈，从而显示出对金黄色葡萄球菌和铜绿假单胞菌的敏感性，这在治疗骨髓炎方面具有巨大潜力。
