再生医学治疗皮肤病：iPS 细胞来拯救。

Regenerative medicine for skin diseases: iPS cells to the rescue.

机构信息

Department of Dermatology and Cutaneous Biology, Jefferson Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

出版信息

J Invest Dermatol. 2011 Apr;131(4):812-4. doi: 10.1038/jid.2011.2.

DOI:10.1038/jid.2011.2

PMID:21407233

Abstract

Induced pluripotent stem (iPS) cells reprogrammed from somatic cells have the potential to differentiate, under appropriate conditions, to any cell type. Recent studies, including two papers in this issue (Bilousova et al., 2011; Tolar et al., 2011), have demonstrated that iPS cells can differentiate into keratinocytes. Thus, iPS cells may provide a novel approach to applying regenerative medicine to cutaneous diseases such as epidermolysis bullosa.

摘要

诱导多能干细胞（iPS）是由体细胞重编程而来的，在适当的条件下，它们具有分化为任何细胞类型的潜能。最近的研究，包括本期的两篇论文（Bilousova 等人，2011 年；Tolar 等人，2011 年），已经证明 iPS 细胞可以分化为角质形成细胞。因此，iPS 细胞可能为应用再生医学治疗如大疱性表皮松解症等皮肤疾病提供了一种新方法。