皮肤组织工程的研究进展：种子细胞、生物支架和构建策略。
Current progress of skin tissue engineering: Seed cells, bioscaffolds, and construction strategies.
机构信息
Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, Shaanxi, China.
Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, Shaanxi, China ; Research and Development Center for Tissue Engineering, College of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, China.
出版信息
Burns Trauma. 2013 Sep 18;1(2):63-72. doi: 10.4103/2321-3868.118928. eCollection 2013.
The development of cell biology, molecular biology, and material science, has been propelling biomimic tissue-engineered skins to become more sophisticated in scientificity and more simplified in practicality. In order to improve the safety, durability, elasticity, biocompatibility, and clinical efficacy of tissue-engineered skin, several powerful seed cells have already found their application in wound repair, and a variety of bioactive scaff olds have been discovered to influence cell fate in epidermogenesis. These exuberant interests provide insights into advanced construction strategies for complex skin mimics. Based on these exciting developments, a complete full-thickness tissue-engineered skin is likely to be generated.
细胞生物学、分子生物学和材料科学的发展，推动了仿生组织工程皮肤在科学性上更加复杂，在实用性上更加简化。为了提高组织工程皮肤的安全性、耐久性、弹性、生物相容性和临床疗效，几种强大的种子细胞已经在伤口修复中得到应用，并且发现了多种生物活性支架来影响表皮发生中的细胞命运。这些旺盛的兴趣为复杂皮肤模拟的先进构建策略提供了思路。基于这些令人兴奋的发展，完整的全厚组织工程皮肤很可能被制造出来。
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