John A E, Morich F J
Department of Analytical Therapy Research, Bayer AG, Wuppertal, West-Germany.
Clin Exp Hypertens A. 1990;12(2):191-204. doi: 10.3109/10641969009074728.
In order to investigate the possible involvement of ANP in the salt dependent hypertension of the DS rats the concentrations of immunoreactive atrial natriuretic peptides (ANP-IR) in atria, plasma and brain of salt loaded and control fed DS and DR rats were determined. On a low salt diet the ANP-IR concentrations in atria, hypothalamus and basal ganglia of DS rats were higher versus DR rats. Salt loading results in a decrease of ANP-IR in left DS atria and an increase in plasma and brain stem of DS rat versus control and DR rat. The data are compared with other studies about ANP performed in Dahl rats, SHR and WKY rats. The possible reasons for the found distribution of ANP-IR are discussed.
为了研究心钠素（ANP）可能参与DS大鼠盐依赖性高血压的机制，我们测定了高盐喂养和对照喂养的DS大鼠及DR大鼠心房、血浆和脑内免疫反应性心钠素（ANP-IR）的浓度。在低盐饮食时，DS大鼠心房、下丘脑和基底神经节中的ANP-IR浓度高于DR大鼠。与对照和DR大鼠相比，高盐饮食导致DS大鼠左心房ANP-IR减少，血浆和脑干中ANP-IR增加。将这些数据与在Dahl大鼠、SHR大鼠和WKY大鼠中进行的其他关于ANP的研究进行了比较。讨论了所发现的ANP-IR分布的可能原因。
