Terrachini V, Provinciali L, Barbara C, Masperone M A, Zanna C, Romeo M, Bruzzone F, Canale C
Cattedra di Malattie dell'Apparato Cardiovascolare, Università degli Studi di Genova.
Clin Ter. 1990 Apr 15;133(1):31-4.
Forty patients with mild-to-moderate arterial hypertension were randomized for double-blind treatment with ketanserin (20 mg b.i.d.) vs. captopril (25 mg b.i.d.) for fifteen days. Diastolic pressure was normalized (less than 90 mmHg) in 11 out of 20 patients of both groups. Of the 18 patients not responding to monotherapy, 17 were treated for 45 days with a combination of both drugs at the same dosages. Diastolic blood pressure was normalized in 15 out of these 17, and in one patient it was reduced by more than 10%. Thus the success rate of therapy was 94%.
40例轻至中度动脉高血压患者被随机分为两组，分别接受为期15天的双盲治疗，一组服用酮色林（20毫克，每日两次），另一组服用卡托普利（25毫克，每日两次）。两组各20例患者中均有11例舒张压恢复正常（低于90毫米汞柱）。在18例对单一疗法无反应的患者中，17例接受了两种药物相同剂量联合治疗45天。这17例患者中有15例舒张压恢复正常，1例患者的舒张压降低了10%以上。因此，治疗成功率为94%。
