Rosenfield M, Gilmartin B, Cunningham E, Dattani N
Schnurmacher Institute for Vision Research, SUNY/State College of Optometry, NY 10010.
Curr Eye Res. 1990 Mar;9(3):267-72. doi: 10.3109/02713689009044522.
This study has examined the effect of an alpha-1 adrenergic agonist (phenylephrine HCl, 2.5%) and a non-selective alpha antagonist (thymoxamine HCl, 0.5%) on tonic accommodation (TA). TA was measured at 1 min intervals throughout a 45 min period using an objective infra-red optometer (Canon Autoref R-1). Additionally pupil diameter and the near-point of accommodation (NPA) were monitored in order to assess the efficacy of the instilled drug. A double-blind protocol was adopted between thymoxamine, phenylephrine and a saline control for 7 emmetropic subjects. There was no significant difference between the values of TA obtained under the three pharmacological conditions. However, both adrenergic agents induced changes in pupil diameter and NPA. Furthermore in all conditions TA increased by approximately 0.25D while the subject sat passively in darkness. The data indicates that alpha-adrenergic innervation alters the closed-loop accommodative response independently of TA.
本研究考察了一种α-1肾上腺素能激动剂（盐酸去氧肾上腺素，2.5%）和一种非选择性α拮抗剂（盐酸百里胺，0.5%）对张力性调节（TA）的影响。使用客观红外验光仪（佳能自动验光仪R-1）在45分钟内每隔1分钟测量一次TA。此外，监测瞳孔直径和调节近点（NPA）以评估所滴注药物的疗效。对7名正视眼受试者采用了盐酸百里胺、盐酸去氧肾上腺素和生理盐水对照的双盲方案。在三种药理学条件下获得的TA值之间没有显著差异。然而，两种肾上腺素能药物均引起瞳孔直径和NPA的变化。此外，在所有条件下，当受试者被动坐在黑暗中时，TA增加约0.25D。数据表明，α-肾上腺素能神经支配独立于TA改变闭环调节反应。
