Carè A, Pelicci P G, Meccia E, Fagioli M, Testa U, Ciccone E, Moretta A, Moretta L, Peschle C
Department of Hematology-Oncology, Istituto Superiore di Sanità, Rome, Italy.
Eur J Immunol. 1990 Apr;20(4):939-42. doi: 10.1002/eji.1830200434.
Investigations on T cell receptor delta chain (TcR delta) gene expression in freshly isolated normal large granular lymphocytes, natural killer (NK) cell clones and NK bulk cultures revealed six T delta transcripts (3.5, 3.1, 2.2, 2.0, 1.5 and 1.3 kb) which varied in number and relative abundance in the different samples. None of the six known T delta variable regions was expressed and the T delta locus was retained in its germ-line configuration. The origin and significance of these NK-associated T delta transcripts are discussed.
对新鲜分离的正常大颗粒淋巴细胞、自然杀伤（NK）细胞克隆及NK大量培养物中T细胞受体δ链（TcRδ）基因表达的研究显示，有六种Tδ转录本（3.5、3.1、2.2、2.0、1.5和1.3 kb），其数量和相对丰度在不同样本中有所不同。六个已知的Tδ可变区均未表达，且Tδ基因座保持其种系构型。本文讨论了这些与NK相关的Tδ转录本的起源及意义。
