血小板衍生生长因子受体-β和血管内皮生长因子受体-2在血管肉瘤患者中的预后意义截然不同。

Contrasting prognostic implications of platelet-derived growth factor receptor-β and vascular endothelial growth factor receptor-2 in patients with angiosarcoma.

机构信息

Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.

出版信息

Ann Surg Oncol. 2011 Oct;18(10):2841-50. doi: 10.1245/s10434-011-1640-4. Epub 2011 Mar 16.

DOI:10.1245/s10434-011-1640-4

PMID:21409488

Abstract

BACKGROUND

Angiosarcoma is an extremely rare tumor among sarcomas and comprises a heterogeneous group of high-grade vascular malignancies. Our study aimed to examine the correlations between 6 immunohistochemical biomarkers-stem cell factor receptor (KIT), platelet-derived growth factor receptor (PDGFR)-α, PDGFR-β, vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, and VEGFR-3-and overall survival (OS) in patients with angiosarcomas.

METHODS

Immunohistochemical analyses for the 6 biomarkers were performed by using tumor specimens obtained from 34 patients with angiosarcomas. Correlations between biomarkers were examined by Fisher's exact test. For each biomarker, the correlation between the immunohistochemical score and OS was examined by the log-rank test and Cox regression analysis.

RESULTS

The percentages of angiosarcoma patients with positive expressions (immunohistochemical score > 0) of KIT, PDGFR-α, PDGFR-β, VEGFR-1, VEGFR-2, and VEGFR-3 were 14.7%, 11.8%, 88.2%, 61.8%, 94.1%, and 100.0%, respectively. No statistically significant correlations between any 2 biomarkers were observed. Cox regression analysis demonstrated a significant positive correlation between short OS and the immunohistochemical score for PDGFR-β and between long OS and the immunohistochemical score for VEGFR-2.

CONCLUSION

Increased expression of PDGFR-β may be a statistically significant prognostic factor for poor OS, while increased expression of VEGFR-2 may be a favorable prognostic factor for patients with angiosarcoma.

摘要

背景

血管肉瘤是肉瘤中一种极其罕见的肿瘤，由一组异质性的高级别血管恶性肿瘤组成。我们的研究旨在探讨 6 种免疫组织化学标志物——干细胞因子受体（KIT）、血小板衍生生长因子受体（PDGFR）-α、PDGFR-β、血管内皮生长因子受体（VEGFR）-1、VEGFR-2 和 VEGFR-3——与血管肉瘤患者总生存（OS）之间的相关性。

方法

采用免疫组织化学分析法对 34 例血管肉瘤患者的肿瘤标本进行 6 种标志物的检测。采用 Fisher 确切概率法对标志物进行相关性分析。采用 log-rank 检验和 Cox 回归分析，对每种标志物的免疫组织化学评分与 OS 之间的相关性进行检验。

结果

KIT、PDGFR-α、PDGFR-β、VEGFR-1、VEGFR-2 和 VEGFR-3 阳性表达（免疫组织化学评分＞0）的血管肉瘤患者比例分别为 14.7%、11.8%、88.2%、61.8%、94.1%和 100.0%。未观察到任何 2 种标志物之间存在统计学显著相关性。Cox 回归分析显示，PDGFR-β 免疫组织化学评分与短 OS 呈显著正相关，VEGFR-2 免疫组织化学评分与长 OS 呈显著正相关。