Farooq Umer, Xiong Guo, Irshad Romana, Yaqoob Shehzad
Xi'an Jiaotong University, Xi'an, Shaanxi, China.
J Ayub Med Coll Abbottabad. 2010 Jan-Mar;22(1):97-100.
Kashin-Beck Disease (KBD) is an endemic osteochondropathy. The disease starts in childhood and attacks the growth of joint cartilage, the joints become deformed and painful, and the worst forms result in dwarfism. The most fiequent joints involved are the finger, wrist, ankles, knees and elbows. In this study the pattern of joints involved in KBD was studied.
A total of 368 patients aged above 13 from 6 villages in endemic areas of the Shaanxi province, located in the northwest of China, were selected through multistage stratified sampling. The patients were diagnosed based on the clinical criteria for diagnosis of KBD. The patients were administered with a battery of questionnaires along with clinical examination for joint involvement.
The patients presented both as oligoarticular as well as polyarticular pattern. Smaller joints were more frequently involved with a proximal-distal pattern. The number of joints involved increased with the severity of the disease.
Proximal smaller joints are more frequently involved in the disease. The involvement of bigger joints takes place in later stages of disease, i.e., in the second and third degree. The pattern of joint involvement shows some correlation with Rheumatoid Arthritis which needs further investigation and comparative studies.
大骨节病（KBD）是一种地方性骨软骨病。该病始于儿童期，侵袭关节软骨生长，导致关节变形、疼痛，最严重的形式会导致侏儒症。最常受累的关节是手指、手腕、脚踝、膝盖和肘部。本研究对大骨节病受累关节的模式进行了研究。
通过多阶段分层抽样，从中国西北部陕西省病区的6个村庄选取了368名13岁以上的患者。根据大骨节病的临床诊断标准对患者进行诊断。对患者进行了一系列问卷调查，并对关节受累情况进行了临床检查。
患者表现为少关节型和多关节型。较小的关节更常受累，呈近端到远端的模式。受累关节的数量随着疾病严重程度的增加而增加。
近端较小的关节更常受累于该病。较大关节的受累发生在疾病的后期，即二度和三度。关节受累模式与类风湿性关节炎有一定相关性，需要进一步调查和比较研究。
