p16(INK4a)/CDKN2 表达及其与口腔鳞状细胞癌的关系：我们目前的认识足够吗？

p16(INK4a)/CDKN2 expression and its relationship with oral squamous cell carcinoma is our current knowledge enough?

机构信息

Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Entrerríos s/n, Santiago de Compostela, C.P. 15782, Spain.

出版信息

Cancer Lett. 2011 Jul 28;306(2):134-41. doi: 10.1016/j.canlet.2011.02.039. Epub 2011 Mar 15.

DOI:10.1016/j.canlet.2011.02.039

PMID:21411222

Abstract

Oral squamous cell carcinomas (OSCC) are the most common malignancy of the oral cavity and their multistep development requires the accumulation of multiple genetic and epigenetic alterations. Inactivation of p16(INK4a), encoded by the CDKN2 gene has been widely associated with this type of tumors. The purpose of this review is to elucidate the relationship between p16(INK4a) expression and the different clinical and pathological aspects of OSCC, analyze the variation in results between studies, detailing the described genetic/epigenetic alterations that result in gene silencing and the relationship between p16(INK4a) and HPV infection.

摘要

口腔鳞状细胞癌（OSCC）是口腔最常见的恶性肿瘤，其多步骤的发展需要多种遗传和表观遗传改变的积累。CDKN2 基因编码的 p16(INK4a)失活与这种类型的肿瘤广泛相关。本综述的目的是阐明 p16(INK4a)表达与 OSCC 的不同临床和病理方面之间的关系，分析研究结果之间的差异，详细描述导致基因沉默的描述性遗传/表观遗传改变以及 p16(INK4a)与 HPV 感染之间的关系。