Division of Oral and Maxillofacial Surgery, Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan.
J Surg Oncol. 2012 Aug 1;106(2):149-54. doi: 10.1002/jso.23067. Epub 2012 Feb 21.
In this study, we examined the role of p16(INK4A) , a surrogate biomarker of HPV-related head and neck cancers with better prognosis, in an endemic area of betel quid (BQ)-related oral squamous cell carcinoma (OSCC).
p16(INK4A) immunohistochemistry was examined in 165 OSCCs, statistical analyses were performed to elucidate the correlation between p16(INK4A) expression and BQ habits/pathologic features, and the prognostic impact of p16(INK4A) and different parameters were analyzed.
The incidence of p16(INK4A) expression was similar between BQ chewers and non-chewers. p16(INK4A) expression was significantly associated with nodal metastasis (P = 0.005). There was a trend suggesting that the loss of p16(INK4A) expression was more frequent in higher T stages, however, this was found only in patients without lymph node metastasis (P = 0.059). A poorer prognosis and a higher risk of tumor recurrence were found in OSCCs without p16(INK4A) expression. (The HR for cancer-specific mortality and cancer recurrence was 3.55 and 1.89, respectively.)
Although it has been suggested that BQ chewers had a greater tendency toward tumor recurrence and poor outcome, our data demonstrated that p16(INK4A) expression is unrelated to BQ habit and that p16(INK4A) downregulation is a strong predictor for OSCC progression, recurrence and survival in Taiwan.
本研究旨在探讨 HPV 相关头颈部癌症的替代生物标志物 p16(INK4A)在槟榔相关口腔鳞状细胞癌（OSCC）高发地区的作用。
对 165 例 OSCC 进行 p16(INK4A)免疫组化检测，统计分析 p16(INK4A)表达与咀嚼槟榔习惯/病理特征的相关性，并分析 p16(INK4A)与不同参数的预后影响。
咀嚼槟榔者与非咀嚼槟榔者的 p16(INK4A)表达发生率相似。p16(INK4A)表达与淋巴结转移显著相关（P=0.005）。有趋势表明，在更高的 T 分期中，p16(INK4A)表达的缺失更为频繁，但仅在无淋巴结转移的患者中发现（P=0.059）。无 p16(INK4A)表达的 OSCC 预后较差，肿瘤复发风险较高。（癌症特异性死亡率和癌症复发的 HR 分别为 3.55 和 1.89。）
尽管有研究表明咀嚼槟榔者肿瘤复发和预后不良的倾向更大，但我们的数据表明，p16(INK4A)表达与咀嚼槟榔习惯无关，p16(INK4A)下调是台湾 OSCC 进展、复发和生存的强预测因子。
