Sirtuin 1 在恶性转化中的作用：是敌是友？

Sirtuin 1 in malignant transformation: friend or foe?

机构信息

Department of Surgery, University of Missouri School of Medicine, Columbia, 65212, USA.

出版信息

Cancer Lett. 2011 Jul 1;306(1):10-4. doi: 10.1016/j.canlet.2011.02.019. Epub 2011 Mar 16.

DOI:10.1016/j.canlet.2011.02.019

Abstract

In the past decade, great interest has been shown in the role of sirtuin 1 (SIRT1) in tumorigenesis. The published data show SIRT1 can function as both a tumor promoter and tumor suppressor. In this review, we summarize the available data regarding the role of SIRT1 in tumorigenesis, with a focus on the potential mechanisms. The seemingly controversial role of SIRT1 in tumorigenesis suggests that SIRT1 might play a dual role in different tissue contexts depending on the temporal and special distribution of different SIRT1 upstream and downstream factors. Clearly, the role of SIRT1 in tumorigenesis is poorly understood and more research is necessary to elucidate its function in the malignant process.

摘要

在过去的十年中，人们对沉默信息调节因子 1（SIRT1）在肿瘤发生中的作用产生了浓厚的兴趣。已发表的数据表明，SIRT1 可以作为肿瘤促进剂和肿瘤抑制剂发挥作用。在这篇综述中，我们总结了关于 SIRT1 在肿瘤发生中的作用的现有数据，重点介绍了潜在的机制。SIRT1 在肿瘤发生中的这种看似矛盾的作用表明，SIRT1 可能在不同的组织环境中发挥双重作用，具体取决于不同 SIRT1 上游和下游因子的时空和特殊分布。显然，SIRT1 在肿瘤发生中的作用还知之甚少，需要进一步研究来阐明其在恶性过程中的功能。