Kratz Ewa Maria, Kokot Izabela, Dymicka-Piekarska Violetta, Piwowar Agnieszka
Department of Laboratory Diagnostics, Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroclaw Medical University, Borowska Street 211A, 50-556 Wroclaw, Poland.
Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona Street 15A, 15-269 Bialystok, Poland.
Antioxidants (Basel). 2021 Jan 10;10(1):84. doi: 10.3390/antiox10010084.
The participation of sirtuins in the regulation of oxidative stress and inflammation lies at the basis of their possible modes of action and is related to their expression in various cell structures; their location in the mitochondria and blood plasma has been indicated as of primary importance. Despite many existing studies, research on sirtuins continues to present an opportunity to discover new functions and dependencies, especially when it comes to women's gynecological health. Sirtuins have a significant role in both the formation and the course of many gynecological diseases. Their role is particularly important and well documented in the course of the development of cancer within the female reproductive organs; however, disturbances observed in the ovary and oocyte as well as in follicular fluid are also widely investigated. Additionally, sirtuins take part in some gynecological disturbances as regulative factors in pathways associated with insulin resistance, glucose and lipids metabolism disorders. In this review, we would like to summarize the existing knowledge about sirtuins in the manner outlined above.
沉默调节蛋白参与氧化应激和炎症调节是其可能作用方式的基础，且与它们在各种细胞结构中的表达有关；它们在线粒体和血浆中的定位已被表明至关重要。尽管已有许多研究，但对沉默调节蛋白的研究仍有机会发现新的功能和相关性，尤其是在女性妇科健康方面。沉默调节蛋白在许多妇科疾病的形成和发展过程中都起着重要作用。它们的作用在女性生殖器官癌症的发展过程中尤为重要且有充分记录；然而，在卵巢、卵母细胞以及卵泡液中观察到的紊乱情况也受到广泛研究。此外，沉默调节蛋白作为与胰岛素抵抗、葡萄糖和脂质代谢紊乱相关途径中的调节因子，参与了一些妇科疾病的发生。在本综述中，我们希望以上述方式总结关于沉默调节蛋白的现有知识。
