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腺病毒载体的操控

Manipulation of adenovirus vectors.

作者信息

Graham F L, Prevec L

机构信息

Departments of Biology and Patholo, McMaster University, Hamilton, Ontario, Canada.

出版信息

Methods Mol Biol. 1991;7:109-28. doi: 10.1385/0-89603-178-0:109.

DOI:10.1385/0-89603-178-0:109
PMID:21416352
Abstract

Adenoviruses have been isolated from a large number of different species (mammalian and fowl) and over 100 different serotypes have been reported, some 43 of them human. The human adenoviruses, particularly types 2, 5, and 12, have been the most extensively characterized, and these viruses have served as valuable tools in the study of the molecular biology of DNA replication, transcription, RNA processing, and protein synthesis in mammalian cells. Seeref. 1 for a general review.

摘要

腺病毒已从大量不同物种(哺乳动物和禽类)中分离出来,已报道有100多种不同血清型,其中约43种为人类腺病毒。人类腺病毒,特别是2型、5型和12型,已得到最广泛的表征,这些病毒已成为研究哺乳动物细胞中DNA复制、转录、RNA加工和蛋白质合成分子生物学的宝贵工具。综述见参考文献1。

相似文献

1
Manipulation of adenovirus vectors.腺病毒载体的操控
Methods Mol Biol. 1991;7:109-28. doi: 10.1385/0-89603-178-0:109.
2
Advantages and disadvantages of multiple different methods of adenoviral vector construction.多种不同腺病毒载体构建方法的优缺点。
Methods Mol Med. 2000;45:189-98. doi: 10.1385/1-59259-079-9:189.
3
CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7.CD46是除3型和7型之外所有B组腺病毒的细胞受体。
J Virol. 2005 Nov;79(22):14429-36. doi: 10.1128/JVI.79.22.14429-14436.2005.
4
Novel complementation cell lines derived from human lung carcinoma A549 cells support the growth of E1-deleted adenovirus vectors.源自人肺癌A549细胞的新型互补细胞系支持E1缺失腺病毒载体的生长。
Gene Ther. 1996 Jan;3(1):75-84.
5
Complete sequence and organization of the human adenovirus serotype 46 genome.人腺病毒46型基因组的完整序列与结构
Virus Res. 2006 Mar;116(1-2):119-28. doi: 10.1016/j.virusres.2005.09.005. Epub 2005 Oct 20.
6
Decreased replication ability of E1-deleted adenoviruses correlates with increased brain tumor malignancy.E1 缺失型腺病毒复制能力的降低与脑肿瘤恶性程度的增加相关。
Cancer Res. 2005 Oct 1;65(19):8936-43. doi: 10.1158/0008-5472.CAN-05-0581.
7
Characterisation of adenoviruses isolated from geese.从鹅中分离出的腺病毒的特性分析。
Avian Pathol. 1984 Apr;13(2):253-64. doi: 10.1080/03079458408418529.
8
Biophysical targeting of adenovirus vectors for gene therapy.用于基因治疗的腺病毒载体的生物物理靶向
Curr Opin Mol Ther. 2000 Oct;2(5):524-31.
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A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity.一种用于评估条件性复制腺病毒治疗效果和毒性的新型体外模型系统。
Clin Cancer Res. 2004 Dec 15;10(24):8697-703. doi: 10.1158/1078-0432.CCR-04-1166.
10
Growth characteristics of human adenoviruses on porcine cell lines.人腺病毒在猪细胞系上的生长特性
Virology. 2008 Apr 10;373(2):400-10. doi: 10.1016/j.virol.2007.12.015. Epub 2008 Jan 11.

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