Jing Yi-Feng, Xia Shu-Jie, Li Du-Jian, Guo Wen-Huan, Xu Yao-Ting
Department of Urology, First Affiliated People Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
Zhonghua Yi Xue Za Zhi. 2011 Feb 15;91(6):412-4.
To investigate the long-term efficacy of ureteral reconstruction with tubularized peritoneal free grafts for the treatment of avulsion of ureteral mucosa in animal models.
The model of avulsion of ureteral mucosa was established in 12 adult dogs. Then they were divided into Group A (n = 6, length of avulsed mucosa at 4 cm) and Group B (n = 6, length of avulsed mucosa at 6 cm). And the tubularized peritoneal free grafts and ureteral stents were implanted into the injured ureters. The curative effect was observed by intravenous urethrogram (IVU) and histological examination at Week 24 post-operation.
Severe stenosis was observed by IVU in 1 dogs in Groups A and B respectively. In the remaining 10 dogs, IVU showed normal size and morphology of kidneys. There was no hydronephrosis. And no obvious stricture of ureteral part was observed for mucosa substitutes made of peritoneal free grafts. In all 10 dogs without stenosis of both groups, peritoneal membrane was replaced by integrated transitional epithelium. And there was no obvious stricture. Collagen fibers were arranged parallel to mucosal surface.
For avulsion of ureteral mucosa under 6 cm, reconstruction with tubularized peritoneal free grafts as mucosa substitutes is an effective method. And its long-term efficacy is satisfactory.
在动物模型中研究采用管状游离腹膜移植进行输尿管重建治疗输尿管黏膜撕脱的长期疗效。
在12只成年犬中建立输尿管黏膜撕脱模型。然后将它们分为A组（n = 6，黏膜撕脱长度为4 cm）和B组（n = 6，黏膜撕脱长度为6 cm）。将管状游离腹膜移植物和输尿管支架植入受伤的输尿管。术后第24周通过静脉尿路造影（IVU）和组织学检查观察疗效。
A组和B组分别有1只犬通过IVU观察到严重狭窄。其余10只犬中，IVU显示肾脏大小和形态正常。无肾积水。对于由游离腹膜移植物制成的黏膜替代物，未观察到输尿管部分明显狭窄。在两组无狭窄的所有10只犬中，腹膜被完整的移行上皮取代。且无明显狭窄。胶原纤维与黏膜表面平行排列。
对于6 cm以下的输尿管黏膜撕脱，采用管状游离腹膜移植物作为黏膜替代物进行重建是一种有效的方法。且其长期疗效令人满意。
