一例罕见的牙龈口腔上皮样肉瘤。

A rare case of oral epithelioid sarcoma of the gingiva.

作者信息

Hagström Jaana, Mesimäki Karri, Apajalahti Satu, Haglund Caj, Rönty Mikko, Sarlomo-Rikala Maarit

机构信息

Department of Pathology/Haartman Institute and HusLab, Helsinki University Central Hospital, Helsinki, Finland.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Apr;111(4):e25-8. doi: 10.1016/j.tripleo.2010.12.014.

DOI:10.1016/j.tripleo.2010.12.014

PMID:21420628

Abstract

Epithelioid sarcoma (ES) is a rare malignant soft tissue tumor. ES can be classified into proximal, distal, and fibroma-like subtypes. These tumors show both mesenchymal and epithelial immunophenotypes. Microscopically, the proximal type ES is usually characterized by nodules of spindle and epithelioid cells growing in granuloma-like pattern often presenting with central necrosis. Immunohistochemically these tumors are vimentin, pancytokeratin, and usually EMA (80%) positive. CD34 (50%) and CD99 (25%) may be positive, and occasionally SMA and S-100 immunopositivity has been reported. No specific genetic alterations have been found in ES. As far as we know, this is the first case in the literature to present ES in gingival mucosa.

摘要

上皮样肉瘤（ES）是一种罕见的恶性软组织肿瘤。ES可分为近端型、远端型和纤维瘤样亚型。这些肿瘤表现出间充质和上皮免疫表型。在显微镜下，近端型ES通常表现为梭形细胞和上皮样细胞结节，呈肉芽肿样生长模式，常伴有中央坏死。免疫组织化学显示，这些肿瘤波形蛋白、全细胞角蛋白阳性，通常上皮膜抗原（EMA）阳性（80%）。CD34（50%）和CD99（25%）可能阳性，偶尔也有平滑肌肌动蛋白（SMA）和S-100免疫阳性的报道。在ES中未发现特定的基因改变。据我们所知，这是文献中首例发生于牙龈黏膜的ES病例。