Department of Endocrinology, The Second Affiliated Hospital, Guangzhou Medical University, 250 Changgang Donglu, Guangzhou 510260, China.
Diabetes Res Clin Pract. 2011 Jul;93(1):17-20. doi: 10.1016/j.diabres.2011.02.025. Epub 2011 Mar 21.
To investigate the HbA(1c) proportion and mortality rate across diabetic patients with severe hypoglycemia and the risk factors for death.
All the diabetic patients with severe hypoglycemia were divided into HbA(1c)<6.5% group and HbA(1c)≥6.5% group. The proportion of HbA(1c), mortality rate and the risk factors for death were analyzed. Common causes for severe hypoglycemia were also analyzed.
The percentages of HbA(1c) in the HbA(1c)<6.5% and HbA(1c)≥6.5% groups were 51.2% and 48.8%, respectively. The mortality rates were not significantly different between the 2 groups (5.3% vs. 5.1%, χ(2)=0.01, p=0.17). Binary logistic regression analysis revealed that in both groups, creatinine, aspartate aminotransferase, and uric acid levels were the risk factors for death. In the HbA(1c)<6.5% and HbA(1c)≥6.5% groups, 65.0% and 64.2% showed common causes of severe hypoglycemia, respectively.
With respect to severe hypoglycemia, equal attention should be paid to patients with an HbA(1c) level of ≥6.5% and those with an HbA(1c) level of <6.5%. The mortality rate is approximately 5% in severe hypoglycemia no matter how the HbA(1c) level is. Creatinine, aspartate aminotransferase, and uric acid are the main risk factors in both groups. Two-thirds of severe hypoglycemia cases could be prevented.
研究严重低血糖的糖尿病患者中 HbA(1c)比例和死亡率以及死亡的危险因素。
所有严重低血糖的糖尿病患者分为 HbA(1c)<6.5%组和 HbA(1c)≥6.5%组。分析 HbA(1c)比例、死亡率和死亡的危险因素。还分析了严重低血糖的常见原因。
HbA(1c)<6.5%组和 HbA(1c)≥6.5%组的 HbA(1c)百分比分别为 51.2%和 48.8%。两组死亡率无显著差异（5.3%比 5.1%，χ(2)=0.01，p=0.17）。二元逻辑回归分析显示，两组中肌酐、天门冬氨酸氨基转移酶和尿酸水平均为死亡的危险因素。在 HbA(1c)<6.5%组和 HbA(1c)≥6.5%组中，分别有 65.0%和 64.2%的患者出现严重低血糖的常见原因。
对于严重低血糖，应同等关注 HbA(1c)水平≥6.5%和 HbA(1c)水平<6.5%的患者。无论 HbA(1c)水平如何，严重低血糖的死亡率约为 5%。肌酐、天门冬氨酸氨基转移酶和尿酸是两组的主要危险因素。三分之二的严重低血糖病例可以预防。
