Moll S, De Moerloose P, Reber G, Schifferli J, Leski M
Department of Medicine, University Cantonal Hospital, Geneva, Switzerland.
Int J Artif Organs. 1990 May;13(5):273-9.
Two hemodialysis membranes, polyacrilonitrile (AN 69) and cellulose acetate (CA), were compared for their effects on complement and hemostasis. Two groups of 5 patients, in dialysis for more than 5 years, were successively dialysed for 4 weeks periods with each type of membrane. We measured C3a (complement activation), platelets and beta-thromboglobulin (platelet activation), thrombin-antithrombin III complexes and fibrinopeptide A (coagulation activation), using C-Reactive Protein as a control for dilution effects. As previously shown, activation of complement was more important with CA than with AN 69 (p less than 0.01). In contrast, activation of coagulation (increase in fibrinopeptide A and thrombin-antithrombin III complexes) was more pronounced with AN 69 than with CA. This study emphasizes the need to consider different biological systems when the bioincompatibility of a hemodialysis membrane is evaluated.
比较了两种血液透析膜，即聚丙烯腈（AN 69）和醋酸纤维素（CA）对补体和止血的影响。两组各5名透析超过5年的患者，先后使用每种类型的膜进行为期4周的透析。我们检测了C3a（补体激活）、血小板和β-血小板球蛋白（血小板激活）、凝血酶-抗凝血酶III复合物和纤维蛋白肽A（凝血激活），使用C反应蛋白作为稀释效应的对照。如先前所示，CA引起的补体激活比AN 69更显著（p<0.01）。相反，AN 69引起的凝血激活（纤维蛋白肽A和凝血酶-抗凝血酶III复合物增加）比CA更明显。这项研究强调，在评估血液透析膜的生物不相容性时，需要考虑不同的生物系统。
