补体激活与生物不相容性。用于评估的末端补体复合物以及用肝素进行表面修饰以改善生物材料。
Complement activation and bioincompatibility. The terminal complement complex for evaluation and surface modification with heparin for improvement of biomaterials.
作者信息
Mollnes T E, Videm V, Riesenfeld J, Garred P, Svennevig J L, Fosse E, Hogasen K, Harboe M
机构信息
Institute of Immunology and Rheumatology, Rikshospitalet, University of Oslo, Norway.
出版信息
Clin Exp Immunol. 1991 Oct;86 Suppl 1(Suppl 1):21-6.
The degree of biocompatibility of biomaterials can be evaluated using various assay systems detecting activation of the blood cascade systems, leukocytes or platelets. Activation of complement is one mechanism associated with adverse effects observed when bioincompatible materials are used. We present data showing that the terminal complement complex, an indicator of terminal pathway activation, is suitable for evaluation of biocompatibility of biomaterials such as cardiopulmonary bypass devices. Furthermore, our results suggest that bioincompatibility is improved when artificial surfaces are modified with end point attached functionally active heparin.
生物材料的生物相容性程度可以通过检测血液级联系统、白细胞或血小板激活的各种分析系统来评估。补体激活是使用生物不相容材料时观察到的不良反应相关的一种机制。我们提供的数据表明，末端补体复合物作为末端途径激活的指标，适用于评估诸如体外循环装置等生物材料的生物相容性。此外，我们的结果表明，当人工表面用末端连接功能活性肝素修饰时，生物不相容性会得到改善。
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