在豚鼠气管和人支气管制剂中，β-拟交感神经药与α-肾上腺素受体阻断药的协同作用。
Potentiation of beta-sympathomimetics with alpha-adrenoceptor blocking drugs in guinea pig trachea and human bronchus preparations.
作者信息
Nousiainen O T, Arnala I, Airaksinen M M, Kokkola K
出版信息
Pharmacology. 1977;15(5):469-77. doi: 10.1159/000136723.
The actions of beta-sympathomimetics alone and in various combinations with alpha-adrenoceptor blocking agents were studied in guinea pig tracheal chain and in some preparations of human bronchi taken in operations. All the alpha-adrenoceptor blockers caused 50-100% potentiation of the effects of the beta-sympathomimetics studied in both preparations, had no effects of their own in the rather low concentrations used (10(-10) --10(-6) mol/l). The results show that guinea pig and human tracheobronchial smooth muscle react similarly to these drugs and may contain adrenergic alpha-receptors.
单独使用β-拟交感神经药以及与α-肾上腺素能受体阻滞剂的各种组合的作用，在豚鼠气管链和一些手术中获取的人支气管制剂中进行了研究。所有的α-肾上腺素能受体阻滞剂在两种制剂中都使所研究的β-拟交感神经药的作用增强了50%-100%，在所用的相当低的浓度（10⁻¹⁰ - 10⁻⁶mol/L）下自身没有作用。结果表明，豚鼠和人的气管支气管平滑肌对这些药物的反应相似，并且可能含有肾上腺素能α受体。
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