Kangas L, Cantell K, Schellekens H
Farmos Group Ltd, Research Center, Turku, The Netherlands.
J Steroid Biochem. 1990 Jun 22;36(3):259-62. doi: 10.1016/0022-4731(90)90021-j.
MFC-7 cells were exposed to toremifene, human alpha and gamma interferons and combinations of them in vitro. Growth of the cells was followed by ATP bioluminescence method. Rats bearing DMBA-induced tumors were treated with toremifene, rat gamma interferon and their combination daily for five weeks. The growth of the tumors was followed by palpation weekly. Toremifene and interferons inhibited the growth of MCF-7 cells. Interferons alpha and gamma were additive; toremifene and interferons were additive or at the best synergistic. Toremifene inhibited the growth of DMBA-induced tumors. Rat gamma interferon alone had no clear effect on the tumor growth. Combination of toremifene and gamma interferone was the most effective treatment and did not show any detectable toxicity. Toremifene and interferons have interesting interactions. Clinical studies using the combination might be warranted.
将MFC - 7细胞在体外暴露于托瑞米芬、人α干扰素和γ干扰素及其组合。采用ATP生物发光法监测细胞生长。用DMBA诱导产生肿瘤的大鼠每天接受托瑞米芬、大鼠γ干扰素及其组合治疗，持续五周。每周通过触诊监测肿瘤生长情况。托瑞米芬和干扰素抑制MCF - 7细胞的生长。α干扰素和γ干扰素具有相加作用；托瑞米芬和干扰素具有相加作用，或至多具有协同作用。托瑞米芬抑制DMBA诱导的肿瘤生长。单独使用大鼠γ干扰素对肿瘤生长没有明显影响。托瑞米芬和γ干扰素的组合是最有效的治疗方法，且未显示出任何可检测到的毒性。托瑞米芬和干扰素具有有趣的相互作用。可能有必要开展使用该组合的临床研究。
