Department of Chemistry, Toho University, 2-2-1 Miyama, Funabashi, Chiba, Japan.
Metallomics. 2011 Jul;3(7):675-9. doi: 10.1039/c1mt00009h. Epub 2011 Mar 18.
Several Zn(II) complexes (2a-e) of 1-arylmethyl-2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates (1a-e), known drug candidates for diabetic complications, were synthesized and proved to have in vitro insulin-mimetic activities, suggesting that these complexes are potential chemotherapeutics that are effective against both diabetes and diabetic complications.
几种 1-芳基甲基-2,5-二氢-4-羟基-5-氧代-1H-吡咯-3-羧酸酯（1a-e）的 Zn(II) 配合物（2a-e）被合成，已知这些化合物是治疗糖尿病并发症的候选药物，并且被证明具有体外胰岛素模拟活性，这表明这些配合物是有效的糖尿病和糖尿病并发症的潜在化学治疗药物。
